Sikiric P. et al.
Editor's note
Sikiric's NO-pathway mechanism paper — BPC 157 modulates nitric-oxide synthesis, competing with both L-arginine and L-NAME. The most-cited mechanistic hook for BPC-157's vascular and healing claims. Single-group work, no independent NO-pathway replication.
Related literature
Pickart L., Margolina A.
Pickart's modern overview of the copper-tripeptide she has been working on since the 1970s. Wound healing, hair, skin, and the lesser-known systemic gene-expression effects — all in one place. The single best entry point to GHK-Cu literature.
Seiwerth S. et al.
The Sikiric group's consolidated wound-healing review — incisional, excisional, burn, diabetic-ulcer, alkali-burn rodent models lined up in one place. Preclinical only; no human RCT exists. Read it to understand the mechanistic claims, not as clinical evidence.
Sikiric P. et al.
Sikiric's theoretical synthesis — BPC 157 framed as a mediator of Robert's cytoprotection concept and Selye's stress response. Useful for understanding why the same lab keeps finding the same effect in everything from gut to tendon to brain. Almost entirely self-citation; weigh accordingly.
Pickart L., Vasquez-Soltero J.M., Margolina A.
Pickart's earlier overview emphasizing GHK-Cu's antioxidant signaling and gene-modulation effects relevant to aging tissues. Mechanistic argument that GHK-Cu's age-dependent plasma decline tracks with the same processes it appears to reverse — interesting hypothesis, mostly cell and animal data behind it.
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