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Research-onlyVendors pendingFacts verified · 2026-05-25

KLOW

Also known as ghk-cu + bpc-157 + tb-500 + kpv blend

KLOW is a compounded multi-peptide blend most commonly formulated as KPV + LL-37 + Orexin (in some vendor lines) but in the dominant marketplace usage today denotes a four-component recovery and skin-support blend of KPV + LL-37 + GHK-Cu (or alternately GHK-Cu) plus a 'Wolverine' tissue-repair pair (BPC-157 + TB-500). Vendor formulations are not standardized: the indexed reference composition for this entry is GHK-Cu + BPC-157 + TB-500 + KPV. It is marketed for skin repair, collagen support, hair density, joint and tendon recovery, gut support, anti-inflammatory effect, and general tissue repair. No human clinical trial of the blend has been conducted; all mechanistic and efficacy claims trace to individual-component primary literature. Compounding ratios, per-component dose, and even component identity vary by supplier — practitioners are advised to verify the exact composition with the vendor before use.

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Formulation note

Standard 4-component KPV + GHK-Cu + BPC-157 + TB-500 blend. Some vendor formulations substitute or omit components — verify per vendor.

What's in this blend

4 components.

Recovery

KPV

KPV (Lysine-Proline-Valine) is the C-terminal tripeptide of alpha-melanocyte-stimulating hormone (alpha-MSH 11-13).

Skin

GHK-Cu

GHK-Cu is the copper(II) complex of the human tripeptide glycyl-L-histidyl-L-lysine (GHK), a naturally occurring fragment first isolated from human plasma in 1973 by Loren Pickart.

Recovery

BPC-157

BPC-157 (Body Protection Compound-157, also designated PL 14736 in the Pliva clinical program) is a synthetic 15-amino-acid pentadecapeptide originally derived from a putative cytoprotective fragment of human gastric juice protein.

Recovery

TB-500

TB-500 is the research-chemical label most commonly applied to a synthetic peptide associated with the actin-binding region of thymosin beta-4 (Tbeta4).

Vendor data

Coming soon.

Per-vendor pricing and verification tiers populate as the SavePeptides crawler comes online. Until then, browse all approved vendors directly.

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Mechanism of action

KLOW has no native pharmacology of its own; its effects derive from the additive activity of its four (or, in some vendor formulations, alternate) components. (1) GHK-Cu — copper(II)-tripeptide that stimulates fibroblast collagen, elastin, and decorin synthesis and modulates >4,000 genes toward a younger transcriptomic profile (Pickart et al.

KLOW has no native pharmacology of its own; its effects derive from the additive activity of its four (or, in some vendor formulations, alternate) components. (1) GHK-Cu — copper(II)-tripeptide that stimulates fibroblast collagen, elastin, and decorin synthesis and modulates >4,000 genes toward a younger transcriptomic profile (Pickart et al., https://pmc.ncbi.nlm.nih.gov/articles/PMC4508379/; https://pmc.ncbi.nlm.nih.gov/articles/PMC6073405/); supports skin and hair-follicle regeneration. (2) BPC-157 — gastric pentadecapeptide acting via VEGFR2-Akt-eNOS angiogenesis and modulation of nitric-oxide signalling, with preclinical tendon, ligament, gut, and CNS repair effects (Hsieh et al., https://pubmed.ncbi.nlm.nih.gov/27847966/; Józwiak et al., https://pmc.ncbi.nlm.nih.gov/articles/PMC11859134/). (3) TB-500 — synthetic Ac-LKKTETQ fragment of thymosin β4 binding G-actin and accelerating cell migration, angiogenesis, and wound healing (Goldstein et al., https://pubmed.ncbi.nlm.nih.gov/22074294/; Malinda et al., https://pubmed.ncbi.nlm.nih.gov/10469335/). (4) KPV — C-terminal α-MSH tripeptide that inhibits NF-κB and IL-1β signalling and reduces pro-inflammatory cytokine secretion (Land et al., https://pmc.ncbi.nlm.nih.gov/articles/PMC3403564/; Brzoska et al., https://pmc.ncbi.nlm.nih.gov/articles/PMC2095288/). No primary literature characterizes pharmacokinetics or pharmacodynamics of the blend as a unit.

Pharmacokinetic properties

Half-life

Varies by component: KPV minutes; GHK-Cu hours; BPC-157 ~4–6 h (rodent SC); TB-500 ~2–3 h. Blended PK has not been studied.

Routes

subcutaneous · topical

Bioavailability

Used SC for systemic effects or topically (compounded cream) for skin, hair, and wound applications. No formal pharmacokinetic data on the blended product.

Amino-acid sequence

Blend (reference composition for this entry): GHK-Cu + BPC-157 + TB-500 + KPV; some vendor formulations substitute LL-37 for one of these components.

Use & research dosing

Skin RepairCollagen SupportHair SupportInjury RecoveryJoint/Tendon SupportGut SupportTissue RepairAnti-InflammatorySkin CalmRecovery

There is no validated human dose for KLOW. Self-experimentation protocols commonly report a single subcutaneous injection delivering roughly 200–500 mcg of each component daily, or a topical (cream) formulation applied 1–2 times daily, in cycles of 4–8 weeks followed by a washout. Because vendor formulations vary in component identity and ratio, the actual milligram-per-component delivery from any given vial of KLOW must be verified from the supplier's certificate of analysis (CoA). No regulatory body has established a human dose; all dosing is extrapolated from the individual-component literature and from informal community reports. Practitioners should compute per-component exposure (BPC-157, TB-500, GHK-Cu, KPV) separately to compare with single-component protocols.

Research-use framing only. SavePeptides sells nothing for human consumption. Doses above reflect reported research / self-experimentation ranges, not clinical recommendations.

Editorial perspective

Blend composition is NOT standardized across vendors — some KLOW preparations substitute LL-37 or another component, and per-component ratios differ. The dominant marketplace reference is a four-way blend of GHK-Cu + BPC-157 + TB-500 + KPV. No human clinical trial of the blend exists; mechanistic claims rely on individual-component primary literature. Always verify the exact component list and per-component dose with the supplier's certificate of analysis.

— SavePeptides editorial desk · last updated 2026-05-25

Cautions & contraindications

Before researching this compound, note:

  • Combined pro-angiogenic load (BPC-157 + TB-500 + GHK-Cu) — theoretical concern in active malignancy
  • LL-37 (when included in some vendor formulations) can be pro-inflammatory and is implicated in rosacea and psoriasis flares
  • Compounded under non-uniform formulations — exact component identity and dose per component vary by vendor
  • No human safety pharmacology data on the blend itself
  • Not FDA-approved
  • Combines a research chemical (BPC-157, 503A Category 2) with other unapproved peptides — regulatory and legal status varies by jurisdiction
  • WADA-prohibited components (BPC-157, TB-500 S0; potentially others)
  • Avoid in pregnancy and lactation due to absent safety data
  • Potential injection-site irritation (multiple components, copper, possible discoloration from GHK-Cu)
  • Quality and sterility of compounded blends varies between vendors
  • Theoretical immunogenicity risk from multi-peptide exposure
  • Discoloration or precipitation in solution may indicate compounding failure — inspect before injecting

Research foundation

The papers behind the page.

  1. [01]https://pmc.ncbi.nlm.nih.gov/articles/PMC4508379/
  2. [02]https://pubmed.ncbi.nlm.nih.gov/27847966/
  3. [03]https://pubmed.ncbi.nlm.nih.gov/22074294/
  4. [04]https://pmc.ncbi.nlm.nih.gov/articles/PMC3403564/
  5. [05]https://pmc.ncbi.nlm.nih.gov/articles/PMC11859134/

Facts verified

2026-05-25

Confidence

low

What this means

  • compounded blend — no human studies of the blend itself
  • vendor formulations vary in component identity and ratio
  • mechanism extrapolated from individual-component primary literature only
  • contains BPC-157 (FDA 503A Category 2 bulk substance)

How we check →

Vendor data coming soon

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003 — Research use

Research-use disclaimer.

SavePeptides surfaces vendor, pricing, and coupon information for research compounds. These products are not intended, approved, or recommended for human consumption. Our content is informational only and does not constitute medical advice.