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PreclinicalVendors pendingFacts verified · 2026-05-25

5-Amino-1MQ (oral tablets)

Also known as 5-Amino-1MQ (Tablets), 5-amino-1-methylquinolinium iodide, nnmt inhibitor, 5-amino-1mq

5-Amino-1MQ (oral tablet form) is the oral presentation of 5-amino-1-methylquinolinium iodide, a small-molecule, membrane-permeable inhibitor of nicotinamide N-methyltransferase (NNMT). It is not a peptide despite being marketed by peptide vendors. NNMT is overexpressed in white adipose tissue and liver in obesity and type-2 diabetes, where it depletes the methyl donor S-adenosylmethionine (SAM) and the NAD+ precursor nicotinamide. Pharmacologic NNMT inhibition with 5-Amino-1MQ has been studied for restoring intracellular NAD+ and SAM pools and for reducing adiposity in diet-induced obese mice. No human-efficacy data have been published; the oral tablet absorption profile in humans is uncharacterized.

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Mechanism of action

5-Amino-1MQ is a nicotinamide-mimetic small molecule that selectively inhibits NNMT at submicromolar potency in adipocyte and hepatocyte assays without inhibiting related SAM-dependent methyltransferases or other NAD+ salvage enzymes (Neelakantan et al., 2018, PMID 29155147).

5-Amino-1MQ is a nicotinamide-mimetic small molecule that selectively inhibits NNMT at submicromolar potency in adipocyte and hepatocyte assays without inhibiting related SAM-dependent methyltransferases or other NAD+ salvage enzymes (Neelakantan et al., 2018, PMID 29155147). NNMT transfers a methyl group from SAM to nicotinamide, generating 1-methylnicotinamide and S-adenosylhomocysteine and consuming both a key methyl donor and the principal NAD+ precursor. By blocking NNMT, 5-Amino-1MQ raises intracellular NAD+ and SAM, restores SIRT1/SIRT3 deacetylase activity, and suppresses lipogenic gene programs. In diet-induced obese mice, systemic 5-Amino-1MQ reduced body weight, white-adipose mass, adipocyte size, and plasma cholesterol without altering food intake (Kannt et al., PMC8337113; PMC7952898). Oral tablet pharmacology in humans is not characterized.

Pharmacokinetic properties

Half-life

limited human data

Routes

oral

Bioavailability

Oral bioavailability not formally characterized in humans. As a small cationic molecule it is expected to have moderate oral absorption but is subject to first-pass metabolism, likely lower systemic exposure than injectable forms at equivalent doses.

Amino-acid sequence

(Not a peptide; nicotinamide N-methyltransferase inhibitor)

Use & research dosing

NNMT InhibitionNAD+ SupportFat LossWeight Loss

Research framing only. There is no human dose-finding study. Self-experimentation protocols in the longevity community typically cite 50-150 mg orally once daily, sometimes divided, run in 4-12 week cycles, back-extrapolated from rodent intraperitoneal doses of approximately 20 mg/kg/day in the Neelakantan and Kannt diet-induced-obesity studies. The oral tablet form has not been characterized for systemic absorption in humans, so the relationship between ingested dose and plasma exposure is unknown. No clinical trial has established a safety threshold or efficacy window. All reported doses should be treated as anecdotal.

Research-use framing only. SavePeptides sells nothing for human consumption. Doses above reflect reported research / self-experimentation ranges, not clinical recommendations.

Editorial perspective

5-Amino-1MQ is a small-molecule NNMT inhibitor, not a peptide, and the oral tablet is the same compound delivered by a route that has not been characterized in humans. The entire efficacy and safety case rests on diet-induced-obesity mouse studies. Marketing as a tablet alongside an injectable is unusual for a peptide-store product and reflects the small-molecule pharmacology. The longevity-community appeal derives from the NAD+/sirtuin narrative rather than from any human evidence.

— SavePeptides editorial desk · last updated 2026-05-25

Cautions & contraindications

Before researching this compound, note:

  • No published human safety, pharmacokinetic, or efficacy data exist
  • All efficacy evidence is from rodent diet-induced-obesity models only
  • Oral tablet absorption and bioavailability in humans are not characterized
  • Not FDA-approved; sold as a research chemical despite oral-tablet presentation
  • Pregnancy and breastfeeding contraindicated (no reproductive toxicity data)
  • Long-term consequences of chronic NNMT inhibition unknown; NNMT has physiologic roles in methyl-group homeostasis
  • Theoretical interactions with methylation-sensitive medications (methotrexate, hydralazine, certain antipsychotics) and high-dose B-vitamin or SAM-e regimens
  • Caution in liver disease or alcohol-use disorder due to potential hepatic methyl-pool perturbation
  • Vendor purity and salt-form identity are not independently verified
  • Compound is a small molecule, not a peptide; structure/activity assumptions from peptide stacks do not apply

Research foundation

The papers behind the page.

  1. [01]https://pubmed.ncbi.nlm.nih.gov/29155147/
  2. [02]https://pmc.ncbi.nlm.nih.gov/articles/PMC8337113/
  3. [03]https://pubmed.ncbi.nlm.nih.gov/35013352/

Facts verified

2026-05-25

Confidence

low

What this means

  • not-a-peptide
  • no-human-data
  • oral-PK-uncharacterized

How we check →

Vendor data coming soon

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Research-use disclaimer.

SavePeptides surfaces vendor, pricing, and coupon information for research compounds. These products are not intended, approved, or recommended for human consumption. Our content is informational only and does not constitute medical advice.

5-Amino-1MQ (oral tablets) · SavePeptides