Also known as 5-amino-1-methylquinolinium, 5-amino-1-methylquinolinium iodide, 5A1MQ, 5-amino-1mq
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule, membrane-permeable, selective inhibitor of nicotinamide N-methyltransferase (NNMT) - it is not a peptide despite being sold by peptide vendors. NNMT methylates nicotinamide (vitamin B3) to 1-methylnicotinamide using S-adenosylmethionine (SAM) as the methyl donor, consuming both the NAD+ precursor and a key cellular methyl donor. NNMT is markedly overexpressed in white adipose tissue and liver in obesity, and pharmacological inhibition has been proposed as a strategy to restore NAD+ pools, increase methylation capacity, and reduce adiposity without altering food intake. 5-Amino-1MQ was developed by Neelakantan and colleagues and characterized in diet-induced obese mice. No clinical human-efficacy data have been published; the compound is sold as a research chemical in both injectable and oral-tablet form despite an entirely preclinical evidence base.
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Browse all vendorsMechanism of action
5-Amino-1MQ is a nicotinamide-mimetic small molecule that selectively inhibits nicotinamide N-methyltransferase (NNMT) at submicromolar potency in adipocyte and hepatocyte assays, without inhibiting related SAM-dependent methyltransferases (e.g.
Pharmacokinetic properties
Half-life
Rodent plasma t1/2 approximately 1-2 h after intraperitoneal dosing (preclinical only); human PK has not been published.
Routes
subcutaneous · intramuscular · oral
Bioavailability
Small molecule (not a peptide), so oral bioavailability is achievable in principle; the marketed oral-tablet form has not been characterized for human absorption. Injectable formulations bypass first-pass metabolism. No human PK data have been published.
Amino-acid sequence
(Not a peptide; small-molecule selective NNMT inhibitor; molecular formula C10H11N2+, parent cation; commonly supplied as the iodide salt)
Use & research dosing
Research framing only. Self-experimentation protocols circulating in the longevity community typically use 50-150 mg orally or subcutaneously per day, sometimes divided into one or two doses, run in 4-12 week cycles. These numbers are loosely back-extrapolated from the rodent intraperitoneal doses of approximately 20 mg/kg/day reported in the Neelakantan et al. diet-induced-obesity studies and are not based on any human dose-finding work. No clinical trial has established a human dose, safety threshold, or efficacy window. The compound is supplied as both an injectable solution and an oral tablet by research-chemical vendors; the oral tablet form has not been characterized for human systemic absorption, and the injectable form bypasses any first-pass effect. Buyers should treat all reported doses as anecdotal.
Research-use framing only. SavePeptides sells nothing for human consumption. Doses above reflect reported research / self-experimentation ranges, not clinical recommendations.
5-Amino-1MQ is not a peptide despite being sold by peptide vendors; it is a membrane-permeable small-molecule NNMT inhibitor developed by the Neelakantan group. The entire efficacy and safety case rests on diet-induced-obesity mouse studies and in-vitro adipocyte work; as of May 2026 no human trial has been registered or published. Marketing as both an oral tablet and an injectable is unusual for a "peptide-store" product and reflects the small-molecule pharmacology. The compound's longevity-community appeal stems from the NAD+/sirtuin narrative rather than from human evidence, and chronic inhibition of an endogenous methyltransferase has poorly characterized long-term consequences.
— SavePeptides editorial desk · last updated 2026-05-25
Cautions & contraindications
Research foundation
Facts verified
2026-05-25
Confidence
low
What this means
Vendor data coming soon
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